
Manisa lies on the main route [wiki=0ef8f876d62a45352e28410454e3634b]Istanbul[/wiki]-[wiki=87da1803d79be02847802fb26ee3f961]Izmir[/wiki] buses take, so has a very high frequency of bus connections from those cities, as well as from [wiki=e93359a4c55245fcee3923156ae5c6b3]Balıkesir[/wiki] and [wiki=85e75f7f6017ec0a620fa92005d5adc5]Bursa[/wiki], both of which also lie on the same route.
Manisa lies on the main railtracks fanning out of [wiki=87da1803d79be02847802fb26ee3f961]Izmir[/wiki] towards north. The city station welcomes trains from Izmir (six times daily), [wiki=b7545e771331ab0cceb32b5a7f7f82b5]Bandırma[/wiki] (twice daily, via [wiki=e93359a4c55245fcee3923156ae5c6b3]Balıkesir[/wiki]-transfering from fast ferries from [wiki=0ef8f876d62a45352e28410454e3634b]Istanbul[/wiki] is possible in this harbour town), [wiki=9221413dd904c157938b397753a8b4bb]Ankara[/wiki] (twice daily, via [wiki=632bf6e4254a0fad039d56f8411d76ab]Eskişehir[/wiki], [wiki=10aeda2dfe374764e33eb14b208b262f]Kütahya[/wiki], and Balıkesir) and [wiki=3f84bb33dba9bf96f76f2fe4e69d11d6]Uşak[/wiki]. There are also trains three times a day from the nearby town of [wiki=493d13d4bcc6508149b8f6162a908c73]Alaşehir[/wiki].
Manisa is on the main [wiki=0ef8f876d62a45352e28410454e3634b]Istanbul[/wiki]-[wiki=e93359a4c55245fcee3923156ae5c6b3]Balıkesir[/wiki]-[wiki=87da1803d79be02847802fb26ee3f961]Izmir[/wiki] highway, numbered D565, as well as the main Izmir-[wiki=9221413dd904c157938b397753a8b4bb]Ankara[/wiki] highway, D300.